Deprogen ARS

Deprogen ARS Review

Tyson Davis

By: Tyson Davis

Betancourt Nutrition employees call Deprogen ARS “the ultimate in PCT (Post Cycle Therapy).” The website claims Deprogen ARS is the only anti-aromatase to feature no proprietary blends, with ingredients designed to limit estrogen and reduce water retention.

This claim is hard to prove, but we can look closer at Deprogen ARS to see if it really is a solid aromatase inhibitor.

Deprogen ARS Ingredients

Deprogen ARS ingredients are unique in that they are selected not only to block estrogen but also to reduce water retention for muscle hardness. Let’s take a look:

Dandelion Root (250 mg). Dandelion is a diuretic, purportedly used in Deprogen ARS to reduce water retention and improve muscle hardness. Dandelion contains urine-promoting chemicals that flush out excess water, but this function is not proven to enhance testosterone or muscle mass. [1]

Indole 3 Carbinol (100 mg). Found in cruciferous vegetables, indole-3-carbinol promotes estrogen metabolism. Just 6-7 mg/kg I3C increased estrogen excretion and reduced estrogen levels. [2] I3C is likely safe but may cause skin rash or increase in liver enzymes. [3]

DIM (50 mg). DIM is a metabolite of I3C and is also an anti-estrogenic. In one study, DIM down-regulated the nuclear estrogen receptor. [4] Small amounts from food are considered safe, but the safety of supplements with larger amounts is unknown . [5]

7-Methoxyflavone (25 mg). In one study evaluating the effects of various flavonoids on estrogen-dependent breast cancer cells, 7-methoxyflavone was found to exhibit anti-estrogen activities. [6] Another study declared 7-methoxyflavone as a potent aromatase inhibitor with potential for cancer prevention. [7] A recommended dosage has not been established.

Boron (5 mg). Although popular in testosterone boosting supplements, boron has not scientifically proven to raise testosterone. In fact, the study cited in the product description itself concludes 2.5 mg boron supplementation does not raise testosterone. [8]

In one study, 10 mg did raise testosterone, but Deprogen ARS does not have enough boron to reach these results. [9] That may be a good thing, however, as high dosages (over 20 mg) may cause infertility and poisoning. [10]

The ingredients in Deprogen ARS are a mixed package. While several—I3C, DIM, and
7-methoxyflavone—have shown to block estrogen in studies, others, like boron and dandelion root, probably won’t make much of a difference.

How to Take Deprogen ARS

The label recommends taking 1 capsule on an empty stomach first thing in the morning and at night. You should not take it for longer than 4 to 6 weeks without at least 2 to 4 weeks of not using it in between.

Deprogen ARS is apparently most effective combined with the testosterone booster Adaptodren. While this supplement is available for around $30 at third party sellers like Amazon.com and MuscleandStrength.com, it is not available on the official website, and Bodybuilding.com says it has been discontinued.

Betancourt Nutrition does not indicate whether you can use Deprogen ARS with other testosterone boosting supplements.

You should not take Deprogen ARS if you are a woman or under 18. Talk to a doctor before using if you have a medical condition. Exceeding recommended serving could result in acne, hair loss, aggressiveness, and irritability. Discontinue use if you experience rapid heartbeat, dizziness, blurred vision, or other symptoms.

Deprogen ARS Pricing

Deprogen ARS comes for the following prices:

• Shop.BetancourtNutrition.com: $59.99
• Bodybuilding.com: $31.98
• MuscleandStrength.com: $31.99
• Amazon.com: $25.50

Deprogen ARS: The Bottom Line

Deprogen ARS has some solid ingredients that should inhibit aromatase and estrogen. It’s not the best aromatase inhibitor I’ve seen, but it should do the job. However, I await customer reviews to see if it works on real people.

References

[1] “Dandelion.” WebMD.com. Available from: http://www.webmd.com/vitamins-supplements/ingredientmono-706-dandelion.aspx?activeIngredientId=706&activeIngredientName=dandelion&source=1

[2] Jon J. Michnovicz et al. “Changes in Levels of Urinary Estrogen Metabolites After Oral Indole-3-Carbinol Treatment in Humans.” JNCI J natl Cancer Inst. 1997; 89 (10): 718-723. Available from: http://jnci.oxfordjournals.org/content/89/10/718.short

[3] “Indole-3-Carbinol.” WebMD.com. Available from: http://www.webmd.com/vitamins-supplements/ingredientmono-1027-INDOLE-3-CARBINOL.aspx?activeIngredientId=1027&activeIngredientName=INDOLE-3-CARBINOL

[4] Chen I et al. “Aryl hydrocarbon receptor-mediated antiestrogenic and antitumorigenic activity of diindolylmethane.” Carcinogenesis. 1998; 19 (9): 1631-9.

[5] “DIINDOLYLMETHANE.” WebMD.com. Available from: http://www.webmd.com/vitamins-supplements/ingredientmono-1049-DIINDOLYLMETHANE.aspx?activeIngredientId=1049&activeIngredientName=DIINDOLYLMETHANE

[6] J.C. Le Bail et al. “Estrogenic and antiproliferative activities on MCF-7 human breast cancer cells by flavonoids.” Cancer Letters. 1998; 130 (1-2): 209-216. Available from: http://www.sciencedirect.com/science/article/pii/S0304383598001414

[7] Nga Ta, Thomas Walle. “Aromatase inhibition by bioavailable methylated flavones.” The Journal of Steroid Biochemistry and Molecular Biology. 2007; 107 (1-2): 127-129. Available from: http://www.sciencedirect.com/science/article/pii/S0960076007001495

[8] Ferrando AA, Green NR. “The effect of boron supplementation on lean body mass, plasma testosterone levels, and strength in male bodybuilders.” Int J Sport Nutr. 1993; 3 (2): 140-9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/8508192

[9] Naghii MR et al. “Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines.” J Trace Elem Med Biol. 2011; 25 (1): 54-8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21129941

[10] “Boron.” WebMD.com. Available from: http://www.webmd.com/vitamins-supplements/ingredientmono-894-boron.aspx?activeIngredientId=894&activeIngredientName=boron&source=1

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